Can I Give My Dog Gas-X?

Yes, with care
Simethicone is commonly referenced for dogs at published doses. Published guidance for dogs: small: 20-40 mg; medium: 40-80 mg; large: 80-160 mg, every 8-12h. Gas discomfort only. Sudden bloated hard abdomen in large breeds = GDV emergency, go to an ER now, do not medicate.
Source: Veterinary Partner (VIN)
Get the exact range for your dog's weight

Skip it or ask a vet first if

suspected GDV/bloat. ER immediately

The safe habit

Confirm any medication decision with your veterinarian, who knows your dog's health history and other medications. VetDose shows published reference data, not prescriptions.

See also

Other GI questions for dogs